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Clarithromycin (500 mg every 8 hours) was given in combination with omeprazole (40 mg daily) to healthy adult subjects. dosis parasetamol 500 mg The steady-state plasma concentrations of omeprazole were increased (C max , AUC 0-24 , and t 1/2 increased by 30%, 89%, and 34%, respectively), by the concomitant administration of clarithromycin. ranexa 500 mg obat apa